Targeting innate immunity for neurodegenerative disorders of the central nervous system
Year: 2016
Type: review
Abstract: Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview of physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia and astrocyte cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article. Neuroinflammation is critically involved in numerous neurodegenerative diseases, and key signaling steps of innate immune activation hence represent promising therapeutic targets. This mini review series originated from the 4th Venusberg Meeting on Neuroinflammation held in Bonn, Germany, 7-9th May 2015, presenting updates on innate immunity in acute brain injury and chronic neurodegenerative disorders, such as traumatic brain injury and Alzheimer's disease, on the role of astrocytes and microglia, as well as technical developments that may help elucidate neuroinflammatory mechanisms and establish clinical relevance. In this meeting report, a brief overview on physiological and pathological microglia morphology is followed by a synopsis on PGE2 receptors, insights into the role of arginine metabolism and further relevant aspects of neuroinflammation in various clinical settings, and concluded by a presentation of technical challenges and solutions when working with microglia cultures. Microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of TREM2 signaling, and the cytokine paradox in Alzheimer's disease are further contributions to this article.
Source: Journal of Neurochemistry
DOI: 10.1111/jnc.13667
Authors: Katrin I. Andreasson, Adam D. Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C. Lee, Donovan Low, Marina A. Lynch, Alon Monsonego, M. Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek‐Blum, Leslie A. Sandusky, Maj‐Linda B. Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J. Van Eldik
Institutions: Stanford Medicine, Stanford University, University of Kentucky, Washington University in St. Louis, Agency for Science, Technology and Research, Singapore Immunology Network, University of Southampton, Cleveland Clinic, Case Western Reserve University, University of South Florida, USF Health Byrd Alzheimer's Institute, Trinity College Dublin, Ben-Gurion University of the Negev, University of Rochester Medicine, University of Rochester, Florey Institute of Neuroscience and Mental Health, Hunter Medical Research Institute, University of Newcastle Australia, University of Gothenburg, Dead Sea and Arava Science Center, Kyoto Pharmaceutical University, Southampton General Hospital, University of Southern California
Language: English
Subfield: Neurology
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Funders: Alzheimer's Association, American Federation for Aging Research, Alzheimer's Drug Discovery Foundation, Pfizer, Cure Alzheimer's Fund, Edward N. and Della L. Thome Memorial Foundation, Wellcome Trust, Higher Education Authority, Science Foundation Ireland, Medicinska Forskningsrådet, National Institutes of Health, Japan Society for the Promotion of Science, Seventh Framework Programme, National Institute on Aging, National Institute of Neurological Disorders and Stroke
Awards: G1113679860, Prostanoid signaling and inflammation in aging and Alzheimer's disease, Functional analysis of stem cell derived-Abeta phagocytic cells for the development of cell therapeutic strategies in Alzheimer's disease, G2086240254, G2204926496, G2855011838, G3094364443, G333805913, Validation of the PGE2 EP4 receptor as a therapeutic target in AD, Preclinical Development of a Selective Suppressor of Neuroinflammation for MCI/AD, G384347443, G4417220376, IL-1 in Neurodegeneration: Development of a New Model, G4579903707, G4722265584, Microglia responses to CNS injury: targeting p38 MAPK signaling, G586710974, G6174725639, The role of fractalkine signaling in neurodegenerative disease, Involvement of myelin integrity in Alzheimer's disease pathogenesis, Mechanism of IL-1 Dependent A-beta Plaque Clearance in Alzheimer's Disease, G9000017672, G9000035486, G9000274855, G9000320515, G9000335555
OpenAlex ID: W2418940280