Effect of steroid therapy on in vitro polymorph migration
Year: 1976
Type: article
Abstract: Steroid therapy in vivo results in stimulation of in vitro polymorph migration. This is not due to a direct effect on polymorphs, but is dependent on the presence of mononuclear leucocytes in the migrating cells. The migration of purified polymorphs from steroid-treated patients is inhibited. Whole serum from steroid-treated patients has no stimulatory effect on polymorph migration, but depletion of the euglobulin fraction renders it stimulatory. It is therefore suggested that steroids in vivo react with mononuclear leucocytes to produce a polymorph migration stimulator. The effect of this factor on polymorphs in the circulation is masked by a euglobulin inhibitor, but in the tissues, it may be relevant to the effects of steroids on polymorph kinetic behaviour.
Source: PubMed Central
Author: Robin Stevenson
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2419403076