Year: 2011
Type: article
Abstract: Depression is a frequent, recurrent and chronic condition with high levels of functional disability (Mueller et al. 1999, Kessler et al. 2003, Posternak 2006.). Depression is also associated with excess allcause mortality (reviewed in: Lepine and Briley 2011). Despite of growing number of different antidepressants, still less than 50% of all patients treated with the currently available antidepressants show full remission and that treatment resistant depression (TRD) occurs frequently in clinical practice (Crisafulli et al. 2011, Fornaro & Giosue 2010). Before starting new strategies for the treatment, we recommend to consider: clinical diagnostic and recognition of relevant features of depression; definition of an adequate treatment; definitions of TRD; our knowledge of the pathogenetic mechanisms of depression and understanding the antidepressant (AD) mechanisms of action.
Source: PubMed
Institutions: University Hospital Centre Zagreb, University of Zagreb
Language: English
Subfield: Pharmacology (medical)
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2421766059