Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
Year: 2016
Type: article
Study design: Observational Study
Source: Nature Genetics
DOI: 10.1038/ng.3552
Authors: LifeLines Cohort Study, Aysu Okbay, Bart M L Baselmans, Jan-Emmanuel De Neve, Patrick Turley, Michel G Nivard, Mark Alan Fontana, S Fleur W Meddens, Richard Karlsson Linnér, Cornelius A Rietveld, Jaime Derringer, Jacob Gratten, James J Lee, Jimmy Z Liu, Ronald de Vlaming, Tarunveer S Ahluwalia, Jadwiga Buchwald, Alana Cavadino, Alexis C Frazier-Wood, Nicholas A Furlotte, Victoria Garfield, Marie Henrike Geisel, Juan R Gonzalez, Saskia Haitjema, Robert Karlsson, Sander W van der Laan, Karl-Heinz Ladwig, Jari Lahti, Sven J van der Lee, Penelope A Lind, Tian Liu, Lindsay Matteson, Evelin Mihailov, Michael B Miller, Camelia C Minica, Ilja M Nolte, Dennis Mook-Kanamori, Peter J van der Most, Christopher Oldmeadow, Yong Qian, Olli Raitakari, Rajesh Rawal, Anu Realo, Rico Rueedi, Börge Schmidt, Albert V Smith, Evie Stergiakouli, Toshiko Tanaka, Kent Taylor, Gudmar Thorleifsson, Juho Wedenoja, Juergen Wellmann, Harm-Jan Westra, Sara M Willems, Wei Zhao, Najaf Amin, Andrew Bakshi, Sven Bergmann, Gyda Bjornsdottir, Patricia A Boyle, Samantha Cherney, Simon R Cox, Gail Davies, Oliver S P Davis, Jun Ding, Nese Direk, Peter Eibich, Rebecca T Emeny, Ghazaleh Fatemifar, Jessica D Faul, Luigi Ferrucci, Andreas J Forstner, Christian Gieger, Richa Gupta, Tamara B Harris, Juliette M Harris, Elizabeth G Holliday, Jouke-Jan Hottenga, Philip L De Jager, Marika A Kaakinen, Eero Kajantie, Ville Karhunen, Ivana Kolcic, Meena Kumari, Lenore J Launer, Lude Franke, Ruifang Li-Gao, David C Liewald, Marisa Koini, Anu Loukola, Pedro Marques-Vidal, Grant W Montgomery, Miriam A Mosing, Lavinia Paternoster, Alison Pattie, Katja E Petrovic, Laura Pulkki-Råback, Lydia Quaye, Katri Räikkönen, Igor Rudan, Rodney J Scott, Jennifer A Smith, Angelina R Sutin, Maciej Trzaskowski, Anna E Vinkhuyzen, Lei Yu, Delilah Zabaneh, John R Attia, David A Bennett, Klaus Berger, Lars Bertram, Dorret I Boomsma, Harold Snieder, Shun-Chiao Chang, Francesco Cucca, Ian J Deary, Cornelia M van Duijn, Johan G Eriksson, Ute Bültmann, Eco J C de Geus, Patrick J F Groenen, Vilmundur Gudnason, Torben Hansen, Catharine A Hartman, Claire M A Haworth, Caroline Hayward, Andrew C Heath, David A Hinds, Elina Hyppönen, William G Iacono, Marjo-Riitta Järvelin, Karl-Heinz Jöckel, Jaakko Kaprio, Sharon L R Kardia, Liisa Keltikangas-Järvinen, Peter Kraft, Laura D Kubzansky, Terho Lehtimäki, Patrik K E Magnusson, Nicholas G Martin, Matt McGue, Andres Metspalu, Melinda Mills, Renée de Mutsert, Albertine J Oldehinkel, Gerard Pasterkamp, Nancy L Pedersen, Robert Plomin, Ozren Polasek, Christine Power, Stephen S Rich, Frits R Rosendaal, Hester M den Ruijter, David Schlessinger, Helena Schmidt, Rauli Svento, Reinhold Schmidt, Behrooz Z Alizadeh, Thorkild I A Sørensen, Tim D Spector, John M Starr, Kari Stefansson, Andrew Steptoe, Antonio Terracciano, Unnur Thorsteinsdottir, A Roy Thurik, Nicholas J Timpson, Henning Tiemeier, André G Uitterlinden, Peter Vollenweider, Gert G Wagner, David R Weir, Jian Yang, Dalton C Conley, George Davey Smith, Albert Hofman, Magnus Johannesson, David I Laibson, Sarah E Medland, Michelle N Meyer, Joseph K Pickrell, Tõnu Esko, Robert F Krueger, Jonathan P Beauchamp, Philipp D Koellinger, Daniel J Benjamin, Meike Bartels, David Cesarini
Institutions: University Medical Center Groningen, University of Groningen, Lifelines, Erasmus University Rotterdam, Erasmus MC, Vrije Universiteit Amsterdam, University of Oxford, Amsterdam Public Health, Harvard University, University of Southern California, University of Amsterdam, University of Illinois Urbana-Champaign, The University of Queensland, University of Minnesota, New York Genome Center, University of Copenhagen, Gentofte Hospital, Copenhagen Prospective Studies on Asthma in Childhood, University of Helsinki, Novo Nordisk Foundation Center for Basic Metabolic Research, Queen Mary University of London, Baylor College of Medicine, South Australian Health and Medical Research Institute, Children's Nutrition Research Center at Baylor College of Medicine, 23andMe (United States), University College London, Essen University Hospital, Center for Research in Environmental Epidemiology, Barcelona Institute for Global Health, Universitat Pompeu Fabra, University Medical Center Utrecht, Centro de Investigación Biomédica en Red, Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública, Karolinska Institutet, Helmholtz Munich, TUM Klinikum, Technical University of Munich, Folkhälsans Forskningscentrum, QIMR Berghofer Medical Research Institute, Max Planck Institute for Human Development, Max Planck Institute for Molecular Genetics, University of Tartu, Leiden University Medical Center, King Faisal Specialist Hospital & Research Centre, Hunter Medical Research Institute, National Institute on Aging, University of Newcastle Australia, University of Turku, Turku University Hospital, University of Warwick, University of Lausanne, SIB Swiss Institute of Bioinformatics, Icelandic Heart Association, University of Iceland, University of Bristol, MRC Integrative Epidemiology Unit, National Institutes of Health, University of California, Los Angeles, The Lundquist Institute, deCODE Genetics (Iceland), University of Münster, Brigham and Women's Hospital, University of Michigan, Rush University Medical Center, RAND Corporation, University of Edinburgh, German Institute for Economic Research, Dartmouth College, Farr Institute, Institute for Social Research, University of Bonn, Life & Brain (Germany), King's College London, Broad Institute, Imperial College London, Oulu University Hospital, University of Oulu, Finnish Institute for Health and Welfare, University of Split, University of Essex, Institute for Social and Economic Research, Medical University of Graz, Centre Hospitalier Universitaire Vaudois, Florida State University, Institute for Integrative and Experimental Genomics, University of Lübeck, Amsterdam Neuroscience, Institute of Genetic and Biomedical Research, National Research Council, Helsinki University Hospital, Institute of Genetics and Cancer, MRC Human Genetics Unit, Washington University in St. Louis, University of South Australia, MRC Centre for Environment and Health, Institute for Molecular Medicine Finland, Fimlab (Finland), Tampere University, University of Tampere, University of Virginia, University of Graz, Frederiksberg Hospital, Bispebjerg Hospital, Alzheimer Scotland, MBS School of Business, Panteia (Netherlands), Technische Universität Berlin, Translational Research Institute, Princeton University, Stockholm School of Economics, Clarkson University, Columbia University, Icahn School of Medicine at Mount Sinai, New York University, Research Institute of Industrial Economics
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: National Science Foundation, University of Southern California, Wellcome Trust, National Institute for Health and Care Research, Vetenskapsrådet, Novo Nordisk Fonden, National Institutes of Health, Medical Research Council, Economic and Social Research Council, National Institute on Aging, National Institute on Drug Abuse, National Institute of Diabetes and Digestive and Kidney Diseases, Office of Behavioral and Social Sciences Research, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, H2020 European Research Council
Awards: Epidemiologic Study of Neural Reserve and Neurobiology of Aging, G1768685568, G2029631211, NIHR Senior Investigator Award, G2620930830, G2638643893, UCLA Clinical and Translational Science Institute, G3343291977, SOCGEN: Combining Social Science and Molecular Genetic Research to Examine Inequality and the Life Course, G3445821079, Aging-related Traits and Disease Risk Factors in a Sardinian Population Cohort, Conducting a genome-wide association study (GWAS) in the English Longitudinal Study of Ageing (ELSA): a unique resource for UK social science, G4083218856, What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping., G4696716500, Risk Factors, Pathology, and Clinical Expressions of AD, G4880584255, Rush Alzheimer's Disease Core Center, G5067462658, NBER Training Program in Aging and Health Economics, The molecular genetic architecture of educational attainment and its significance for cognitive health, G6689231961, NIHR Senior Investigator Award, Adult consequences of youth substance use: Twin study enriched for SUD risk, Twin Family Study of Vulnerability to Substance Abuse, G8137569311, Infrastructure for the Office of Population Research, Risk Factors, Pathology, and Clinical Expressions of AD, Genome-Wide Analyses of Health and Well-Being Phenotypes, Personality Change as an Early Marker of Alzheimer's Disease, Understanding and Improving Healthcare Decision-Making and Outcomes for People Living with Alzheimer's Disease and Related Dementias, NBER Center for Aging and Health Research, Diabetes Research Center (DRC), Health and Retirement Study: Yrs 35-40, CENTRE FOR ECONOMIC PERFORMANCE 2015-2020
OpenAlex ID: W2336993262