Work

Mini-review: Does Notch promote or suppress cancer? New findings and old controversies.

Year: 2015

Type: review

Abstract: Notch signaling in tumorigenesis and cancer progression presents a certain enigma. Numerous experimental studies reported significant effects in cancer, yet of varying magnitude and opposite sign. This mini review is aimed to streamline our understanding of the Notch role in tumor progression, and outline future experiments to clarify the modality of Notch function and perspectives of the Notch-based anticancer treatments.

Source: Europe PMC (PubMed Central)

Author: Irina B Grishina

Institutions: New York University, New York City College of Technology

Language: English

Topic: Developmental Biology and Gene Regulation

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2430405054

FWCI: 0.248

Cites: 31

Cited by: 11

Related to: 10