Work

Clinical Validation of Chemotherapy Response Biomarker ERCC2 in Muscle-Invasive Urothelial Bladder Carcinoma

Year: 2016

Type: article

Abstract: 10 PD events were colon and prostate cancer, which were also unrelated to earlier PD (Table 2).Discussion | Both cancer and PD occur primarily at advanced ages and can be debilitating.Consequently, medical surveillance for cancer could be influenced by a prior PD diagnosis, which may bias the observed PD-cancer associations.Moreover, patterns of medical surveillance may differ by health care system (eg, US Medicare and Taiwan National Health Insurance Research Database).It is therefore important that in evaluating PD-cancer associations investigators adjust for medical surveillance and include negative controls.Although we cannot rule out small risks attributable to sample size, we did not find a positive association between PD and subsequent cancer in Asian Americans in SEER-Medicare data.Although according to SEER-Medicare data Asian Americans are ethnically more diverse than the Taiwanese population, our null findings do not support the hypothesis that ethnicity is a major contributor to the elevated risk in the study by Lin et al. 4 The elevated risks observed in the study by Lin et al 4 could reflect various factors, including possibly more cancer surveillance after PD.

Source: JAMA Oncology

DOI: 10.1001/jamaoncol.2016.1056