Work

Pre-exposure to fine particulate matters may induce endotoxin tolerance in a mouse model.

Year: 2015

Type: article

Abstract: Exposure to low or moderate doses of lipopolysaccharides (LPS) renders the host tolerance to a subsequent lethal dose of LPS, which is termed as endotoxin tolerance. It is characterized as the decrease in production of pro-inflammatory cytokines and the increase in production of anti-inflammatory mediators in response to a second LPS challenge. The alteration of cytokine profile protects LPS-primed hosts against a normally lethal dose of subsequent LPS challenge. Nevertheless, whether other environmental factors also trigger endotoxin tolerance remains unclear. Both epidemiologic and experimental studies have provided a link between particulate matter and human health. Here, we speculated on the effect of fine particles priming on endotoxin tolerance in a mouse model.

Source: PubMed

Authors: Yuntao Bai, Bo Lu, Qinghua Sun

Institution: The Ohio State University

Language: English

Topic: Immune Response and Inflammation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute of Environmental Health Sciences

Awards: Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?, Air Pollution on Adiposity and Vascular Dysfunction: White or Brown Matters?