Work

Computational Assessment of Neural Probe and Brain Tissue Interface under Transient Motion

Year: 2016

Type: article

Abstract: The functional longevity of a neural probe is dependent upon its ability to minimize injury risk during the insertion and recording period in vivo, which could be related to motion-related strain between the probe and surrounding tissue. A series of finite element analyses was conducted to study the extent of the strain induced within the brain in an area around a neural probe. This study focuses on the transient behavior of neural probe and brain tissue interface with a viscoelastic model. Different stages of the interface from initial insertion of neural probe to full bonding of the probe by astro-glial sheath formation are simulated utilizing analytical tools to investigate the effects of relative motion between the neural probe and the brain while friction coefficients and kinematic frequencies are varied. The analyses can provide an in-depth look at the quantitative benefits behind using soft materials for neural probes.

Source: Biosensors

DOI: 10.3390/bios6020027

Authors: Michael Polanco, Sebastian Bawab, Hargsoon Yoon

Institutions: Old Dominion University, Norfolk State University

Language: English

Topic: Neuroscience and Neural Engineering

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: gold

Estimated APC paid: $2,654

Funders: National Science Foundation, Core Research for Evolutional Science and Technology