A control clinicial trial of a new anxiolytic 'clobazam'.
Year: 1984
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: Clobazam as a twice-a-day dosage (10 mg-20 mg) regimen and Diazepam in a thrice-a-day schedule (5 mg-5 mg-5 mg) were both effective in controlling moderate to severe anxiety neurosis. 83 patients were studied in a controlled, randomised, double-blind trial. Patients received active drug for the first six weeks and placebo for the next two weeks. Weekly evaluation was performed clinically for anxiolytic effect as well as effect on motor coordination studied on the Pursuit Rotor. Clobazam did not significantly differ from Diazepam in the dosage schedules studied. At the end of the two-week placebo treatment period, patients on Clobazam showed more improvement. Motor coordination was not impaired in both treatment groups. Clobazam treated patients had better motor performance at the end of the 14-day post-treatment placebo period. Side effects were reported with equal frequency in both the populations.
Source: PubMed Central
Authors: G Singh, V Kumar, R Kapur
Institution: Government Medical College
Language: English
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: green
OpenAlex ID: W2435896359