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Defibrotide for Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome with Multi-Organ Dysfunction: A Concordance Analysis Between Day+100 Complete Response and Survival

Year: 2016
Type: article
Abstract: Hepatic veno-occlusive disease, also called sinusoidal obstruction syndrome (VOD/SOS), is a potentially life-threatening complication of hematopoietic stem cell transplant (HSCT) conditioning, which may cause injury to sinusoidal endothelial cells and hepatocytes. Severe VOD/SOS (typically defined by multi-organ dysfunction [MOD]) may be associated with >80% mortality. Defibrotide has a proposed mechanism of action that includes stabilization of endothelial cells and restoration of thrombo-fibrinolytic balance.
DOI: 10.1016/j.bbmt.2015.11.846
Authors: Paul G. Richardson, Marcie L. Riches, Nancy A. Kernan, Joel A. Brochstein, Shin Mineishi, Amanda M. Termuhlen, Sally Arai, Stephan A. Grupp, Maja Miloslavsky, Bijan Nejadnik, Alison L. Hannah, Robert J. Soiffer
Institutions: Harvard University, Dana-Farber Cancer Institute, University of North Carolina at Chapel Hill, University of North Carolina Hospitals, Memorial Sloan Kettering Cancer Center, Cohen Children's Medical Center, University of Alabama at Birmingham, Children's Hospital of Los Angeles, Stanford Medicine, Children's Hospital of Philadelphia, Jazz Pharmaceuticals (United States)
Language: English
Subfield: Hematology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,650
OpenAlex ID: W2437100844
FWCI:
Cites:
Cited by: 1
Related to: 10