Work

Effectiveness of differentiation inducers in combination on human neuroblastoma cells in vitro.

Year: 1989

Type: article

Abstract: The effects of epirubicin and retinoic acid (RA) as differentiation inducing agents on human neuroblastoma cell lines were investigated. We have compared the response of neuroblastoma cells to epirubicin alone, to RA alone and to combined treatment, with respect to neuritic processes outgrowth, acethylcholinesterase activity, growth inhibition and antigenic expression. The obtained data indicate that the combination of the two agents is able to produce a synergistic effect on differentiation and on growth inhibition.

Source: PubMed

Authors: P Rocchi, G Simone, A Lorenzetti, D Granchi, P Paolucci, G Paolucci

Institutions: University of Bologna, Istituto Ortopedico Rizzoli

Language: English

Topic: Neuroblastoma Research and Treatments

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2438147659

FWCI:

Cites:

Cited by: 1

Related to: 10