Antibodies cross-reactive with DNA and cardiolipin in patients with systemic lupus erythematosus.
Year: 1982
Type: article
Study design: Observational Study
Abstract: Using a modified solid phase radioimmunoassay (RIA), sera from 11 patients with systemic lupus erythematosus (SLE) that had high DNA binding activities were analysed for their ability to cross-react with phospholipids. Polyspecific anti-DNA antibodies that reacted with both ssDNA and dsDNA had the ability to cross-react with phospholipids, especially cardiolipin. The relationship between biological false-positive serological tests for syphilis (BFP-STS) and the magnitude of serum anti-DNA antibody levels is also discussed.
Source: PubMed
Authors: T Koike, H Tomioka, A Kumagai
Language: English
Subfield: Rheumatology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2438218489