Work

Relationship between CIP2A expression, and prognosis and MDR-related proteins in patients with advanced gastric cancer.

Year: 2015

Type: article

Abstract: CIP2A is highly expressed in a variety of malignancies. We determined the expression and clinical significance of CIP2A in patients with advanced gastric cancer. CIP2A protein was expressed in 25 of 37 cancer tissue specimens. There was no correlation between CIP2A and PGP, GST-π, Topo-II, and LRP expression. Survival analysis showed significant differences between the survival rate of the CIP2A protein-positive and -negative groups (χ(2)=4.509, P=0.034), but the degree of positive expression was unrelated to survival time (χ(2)=4.639, P=0.098). CIP2A expression may have no prospective value for optimizing chemotherapy regimens, but it can be an indicator for patient prognosis.

Source: PubMed

Authors: Jian-Shi Chen, Bin-Bin Wu, Hai-Li Bao, Ji-Mei Du, Sheng-Chu Zhang, Yi-Hu Zheng

Institutions: Wenzhou Medical University, Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University, First Affiliated Hospital of Wenzhou Medical University, China Three Gorges University, Yichang Central People's Hospital

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2441186080

FWCI: 0.599

Cites: 19

Cited by: 10

Related to: 10