Effect Modification by Time Since Blood Draw on the Association Between Circulating Fatty Acids and Prostate Cancer Risk
Year: 2016
Type: article
Abstract: A recent meta-analysis suggested that circulating fatty acids do not play an important role in prostate carcinogenesis. We hypothesized that the relation between circulating fatty acids and prostate cancer (PCa) risk is modified by time between blood draw and diagnosis. We tested this hypothesis in a prospective case-control study of 476 PCa cases and matched control subjects nested in the Physicians' Health Study. The previously reported associations between fatty acids and PCa in this cohort were dramatically stronger among men diagnosed 10 or more years after blood collection. Statistically significant effect modification by time since blood collection was identified for mono-unsaturated and poly-unsaturated fatty acids and was more pronounced for aggressive tumors. Among men diagnosed fewer than 10 years since blood collection, the relative risks per interquartile range were 1.03 (95% confidence interval [CI] = 0.86 to 1.25) for total mono-unsaturated fatty acids (MUFA) and 0.95 (95% CI = 0.78 to 1.15) for total poly-unsaturated fatty acids (PUFA) whereas among men diagnosed 10 or more years after blood draw the relative risks per interquartile range were 1.69 (95% CI = 1.21 to 2.34) for MUFA (Pheterogeneity = .01) and 0.59 (95% CI = 0.42 to 0.83) for PUFA (Pheterogeneity = .02). These data suggest that the results of the meta-analysis may be partly explained by insufficient follow-up time. Furthermore, they suggest that some environmental and metabolic factors may play a role in prostate carcinogenesis decades before clinical identification of this disease.
DOI: 10.1093/jnci/djw141
Authors: Meng Yang, Howard D. Sesso, Graham A. Colditz, Jing Ma, Meir J. Stampfer, Jorge E. Chavarro
Language: English
Subfield: Nutrition and Dietetics
Field: Nursing
Domain: Health Sciences
Open Access status: bronze
Awards: G1318872084, PHYSICIANS HEALTH STUDY--CONTINUED FOLLOW UP, Nutritional and Biochemical/Genetic Markers of Cancer, DF/HCC SPORE in Prostate Cancer, Molecular Link Between Metabolic Syndrome and Prostate Cancer, DE NOVO LIPOGENESIS, FAT INTAKE, AND PROSTATE CANCER SURVIVAL, A MULTILEVEL APPROACH TO ENERGY BALANCE AND CANCER ACROSS THE LIFECOURSE, Boston Nutrition Obesity Research Center, G3780238105, Dietary and Hormonal Determinants of Cancer in Women, G4119534169, G4522543292, Hormones and Cytokines in CaP risk and recurrence, Physicians' Health Study II: Prevention Trial of Vitamins, Harvard Transdisciplinary Research in Energetics and Cancer Center, MOLECULAR DYNAMICS IN CELLULAR AGING: A SYNTHETIC BIOLOGY APPROACH., G5850682332, Growth Factors and Lethal Prostate Cancer Signature, Growth Factors and Prostate Cancer Risk, TRIAL OF ASPIRIN AND BETA-CAROTENE IN U S MD'S, G939971039
OpenAlex ID: W2441559295