Work

Ro-06incidence of Cataract Development in Pediatric Patients Receiving Craniospinal Irradiation

Year: 2016

Type: article

Abstract: OBJECTIVE: Craniospinal irradiation (CSI) is an important component of therapy for some children with brain tumors. CSI has been associated with numerous late effects, but there is a paucity of data regarding cataract development following CSI. We investigated the incidence of cataracts in children treated at our institution. METHODS: Single center retrospective analysis of children with primary intracranial neoplasms who received CSI between 07/2007 and 06/2015. Data included tumor histology and location, radiation dose, cataract development and intervention. RESULTS: Sixty-five children received CSI over that time period (57 embryonal tumors, 5 germ cell tumors, 3 pineal tumors) and 46 had eye exams. Median CSI dose was 23.4 Gy (range 12 - 36 Gy). With a median follow up of 25.0 months, thirteen (28%) developed cataracts with a median time to develop cataracts of 27.6 months (range 20-60 months). Six have required intervention. CONCLUSIONS: Development of cataracts is a significant risk in children who require CSI for the treatment of a brain tumor. Routine eye exams should be included with long term follow-up. Further study will better delineate risk factors for the development of cataracts, allowing appropriate screening and management for these patients.

Source: Neuro-Oncology

DOI: 10.1093/neuonc/now082.06