Acidic extracellular pH of tumors induces octamer-binding transcription factor 4 expression in murine fibroblasts in vitro and in vivo
Year: 2016
Type: article
Abstract: Octamer-binding transcription factor 4 (OCT-4) is an important marker of cellular de-differentiation that can be induced by environmental stressors, such as acidity. Here we demonstrate that chronic acidic stress in solid tumors induced OCT-4 expression in fibroblasts and other stromal cells in four tumor models. The results have implications for how tumors utilize pH modulation to recruit associated stromal cells, induce partial reprogramming of tumor-associated stromal cells, and respond to therapy.
Source: Scientific Reports
DOI: 10.1038/srep27803
Institution: Washington University in St. Louis
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Awards: Center for Multiple Myeloma Nanotherapy, G1798318495, WU-MDACC Inter-Institutional Molecular Imaging Center, G446245888, FLUORESCENCE LIFETIME IMAGING MICROSCOPY SYSTEM, NEAR INFRARED PH-SENSITIVE MOLECULAR PROBES FOR MICROSCOPY OF CELLS AND TISSUES, G6594705016, A NOVEL EXTRACELLULAR AND INTRACELLULAR TREATMENT PARADIGM FOR ERADICATING CANCER, DEVELOPMENT OF GOGGLE SYSTEM FOR FLUORESCENCE IMAGE-GUIDED SURGERY, IVIS LUMINA II XR FOR OPTICAL IMAGING OF RADIOPHARMACEUTICALS, G9000024588, G9000158788
OpenAlex ID: W2443069878