Abolition of Individual Antioxidant Enzymes Did Not Affect Antibiotic-mediated Killing of Escherichia coli
Year: 2026
Type: article
Abstract: Three classes of bactericidal antibiotics induce oxidative damages in addition to their interactions with specific intracellular targets. By utilizing knockout strains of Escherichia coli that lack antioxidant enzymes, we investigated whether deficiencies in the oxidant scavenging pathways would render the mutants more susceptible to ampicillin, norfloxacin and tobramycin. Although the antibiotics mediated detectable increase in oxidative stress, abolishing each of the antioxidant enzymes, manganese superoxide dismutase, hydroperoxidase I or alkyl hydroperoxide reductase did not increase the antibiotic susceptibilities of E. coli. We concluded each of the three enzymes by itself was not essential in the defense against antibiotic-mediated killing.
Source: Open Collections
Authors: Lee, Janet, Wang, Sophie, Wei, Vivien, Wu, Dan
Institution: University of British Columbia
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2444336527