Pseudomonas aeruginosa forms biofilms in acute infection independent of cell-to-cell signaling.
Year: 2007
Type: article
Abstract: Biofilms are bacterial communities residing within a polysaccharide matrix that are associated with persistence and antibiotic resistance in chronic infections. We show that the opportunistic pathogen Pseudomonas aeruginosa forms biofilms within 8 h of infection in thermally injured mice, demonstrating that biofilms contribute to bacterial colonization in acute infections as well. Using light, electron, and confocal scanning laser microscopy, P. aeruginosa biofilms were visualized within burned tissue surrounding blood vessels and adipose cells. Although quorum sensing (QS), a bacterial signaling mechanism, coordinates differentiation of biofilms in vitro, wild-type and QS-deficient P. aeruginosa strains formed similar biofilms in vivo. Our findings demonstrate that P. aeruginosa forms biofilms on specific host tissues independently of QS.
Source: PubMed Central
DOI: 10.1128/iai.00586-07
Authors: J Andy Schaber, W Jeffrey Triffo, Sang Jin Suh, Jeffrey W Oliver, Mary Catherine Hastert, John A Griswold, Manfred Auer, Abdul N Hamood, Kendra P Rumbaugh
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W246076224