Year: 1977
Type: dissertation
Abstract: Intravenous infusion of arrhythmogenic drug solutions was used as a pharmacological tool to measure the ventricular fibrillation threshold.Reserpinized animals increased the fibrillation thresh old of McN2165.Animals reserpinized two weeks prior to the ex periment still demonstrated an increased fibrillation threshold.Pronethalol, norepinephine, phenoxybenzamine, and neostigmine all increased the fibrillation threshold of McN2165, while atropine produced no change.Isoproterenol was the only drug that lowered the threshold.Reserpinized animals pretreated with norepinephrine still demonstrated an increased fibrillation threshold.Isopro terenol decreased the threshold even when the animals were reser pinized.Pronethaloel was able to suspend the fibrillation induced by McN2165.Beta receptors appear to be involved in the induction ventricular fibrillation by McN2165.Reserpine and pronethalol both increased the fibrillation thresh old of strophanthin K, while isoproterenol lowered the threshold.Pronethalol was not able to suspend the fibrillation induced by strophanthin K. Reserpine, pronethalol, and isoproterenol all increased the fi brillation threshold of barium chloride and pronethalol could not suspend the fibrillation induced by it.Normal administration of reserpine and isoproterenol did not change the threshold of aconitine.Pronethalol and intraperitoneal injection of reserpine increased the fibrillation threshold.Pronethalol was also unable to stop the fibrillation induced by aconitine.The arrhythmogenic action of McN2165 is different from any other arrhythmogenic agent used in this study.
Source: The Mathematics Enthusiast
Author: Edward K.L. Chan
Institution: University of Montana
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2460841279