Work

On the track of absolute enantioselective catalysis

Year: 2008

Type: article

Abstract: The main goal of this communication is to show the utility of empirical approaches combined with mathematical methods in the research regarding the molecular basis of biological chirality. Preparative results (enantiomeric excesses, e.e.) obtained in asymmetric autocatalysis with (AAC) and without (AES) chiral additive were analyzed. Statistical calculations show, that AES (absolute enantioselective synthesis) experiments yield two independent groups of results with prevalence of the R- or S-enantiomer. These are distributed asymmetrically in a second-order beta distribution. Empirical calculations both on AAC and EAS enable to identify the very low (statistical) e.e.-s amplified by AES. These initial e.e.-s show normal distribution. Possible molecular-level reasons of these results were controlled by quantum chemical MO calculations and compatible mechanism(s) are discussed.

Source: University of Debrecen Electronic Archive (University of Debrecen)

Authors: Luciano Caglioti, Béla Barabás, Francesco Faglioni, Nicola Florini, Paolo Lazzeretti, Marco Maioli, Károly Micskei, Gyula Rábai, Ferdinando Taddei, Claudia Zucchi, Gyula Pályi

Institutions: Sapienza University of Rome, Budapest University of Technology and Economics, University of Modena and Reggio Emilia, University of Debrecen

Language: English

Topic: Asymmetric Synthesis and Catalysis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

OpenAlex ID: W2461066938

FWCI: 0.314

Cites:

Cited by: 5

Related to: 10