The association of maternal vitamin D status with infant birth outcomes, postnatal growth and adiposity in the first 2 years of life in a multi-ethnic Asian population: the Growing Up in Singapore Towards healthy Outcomes (GUSTO) cohort study
Year: 2016
Type: article
Study design: Observational Study
Abstract: Maternal vitamin D status during pregnancy has been associated with infant birth and postnatal growth outcomes, but reported findings have been inconsistent, especially in relation to postnatal growth and adiposity outcomes. In a mother-offspring cohort in Singapore, maternal plasma vitamin D was measured between 26 and 28 weeks of gestation, and anthropometric measurements were obtained from singleton offspring during the first 2 years of life with 3-month follow-up intervals to examine birth, growth and adiposity outcomes. Associations were analysed using multivariable linear regression. Of a total of 910 mothers, 13·2 % were vitamin D deficient (<50 nmol/l) and 26·5 % were insufficient (50-75 nmol/l). After adjustment for potential confounders and multiple testing, no statistically significant associations were observed between maternal vitamin D status and any of the birth outcomes - small for gestational age (OR 1·00; 95 % CI 0·56, 1·79) and pre-term birth (OR 1·16; 95 % CI 0·64, 2·11) - growth outcomes - weight-for-age z-scores, length-for-age z-scores, circumferences of the head, abdomen and mid-arm at birth or postnatally - and adiposity outcomes - BMI, and skinfold thickness (triceps, biceps and subscapular) at birth or postnatally. Maternal vitamin D status in pregnancy did not influence infant birth outcomes, postnatal growth and adiposity outcomes in this cohort, perhaps due to the low prevalence (1·6 % of the cohort) of severe maternal vitamin D deficiency (defined as of <30·0 nmol/l) in our population.
Source: British Journal Of Nutrition
Institutions: Agency for Science, Technology and Research, Singapore Institute for Clinical Sciences, National University of Singapore, National University Health System, Erasmus MC, Southampton General Hospital, University Hospital Southampton NHS Foundation Trust, NIHR Southampton Biomedical Research Centre, MRC Lifecourse Epidemiology Unit, University of Southampton, University of Auckland, KK Women's and Children's Hospital, Duke-NUS Medical School, Clinical Nutrition Research Centre
Language: English
Topic: Vitamin D Research Studies
Subfield: Pathology and Forensic Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Funders: Danone, National Institute for Health and Care Research, British Heart Foundation, National Research Foundation, Singapore Institute for Clinical Sciences, National Research Foundation Singapore, National University Health System, Versus Arthritis, Nestec, Medical Research Council, National Medical Research Council
Awards: G1882858428, G1917706474, G1956390128, G213766589, G2780654756, G3210728687, NIHR Senior Investigator Award, G3778457340, G3873828540, G5056894301, RENEWAL: Maternal and epigenetic determinants of cardiovascular structure and function, NIHR Senior Investigator Award, G5755632036, G606602278, G6219046052, G6408020244, Lifecourse Determinants of Bone and Joint Disease, NIHR Senior Investigator Award, G8346907872, Nutrition, Development and Lifelong Health: Studies in European Populations, Maternal vitamin B12, folic acid and homocysteine as determinants of gestational diabetes, fetal growth and intergenerational programming of diabesity, G8537882575, G8606453147
OpenAlex ID: W2461701006