Work

Telomerase, Autophagy and Acute Kidney Injury

Year: 2016

Type: article

Abstract: In humans, aging is associated with telomere shortening and increased susceptibility to acute kidney injury. Telomerase is essential to maintain telomere length. The fourth generation mice with telomerase deletion have progressive shortening of telomeres. Those mice delayed recovery from ischemia-reperfusion injury, due to an increase in tubule cell senescence and impairment of autophagy, the latter of which may be mediated in part by increased mTOR signaling. © 2016 S. Karger AG, Basel.

Source: The Nephron journals/Nephron journals

DOI: 10.1159/000446665

Authors: Raymond C. Harris, Huifang Cheng

Institutions: United States Department of Veterans Affairs, Nashville VA Medical Center, Vanderbilt University

Language: English

Topic: Acute Kidney Injury Research

Subfield: Nephrology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: U.S. Department of Veterans Affairs, National Institute of Diabetes and Digestive and Kidney Diseases