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Experimental and Clinical Pharmacology: Renin inhibitors - mechanisms of action

Year: 2009

Type: article

Abstract: Renin inhibitors are antihypertensive drugs which block the first step in the renin-angiotensin system.Their mechanism of action differs from that of angiotensin converting enzyme inhibitors and angiotensin receptor antagonists, but like these drugs, renin inhibitors interrupt the negative feedback effects of angiotensin II on renin secretion.This increases renin concentrations which may attenuate the inhibition of the reninangiotensin system by these therapies.Renin inhibitors may interfere with measurements of renin in plasma.

Source: Australian Prescriber

DOI: 10.18773/austprescr.2009.064

Author: Duncan Campbell

Institutions: The University of Melbourne, St Vincent's Hospital Melbourne, St Vincents Institute of Medical Research

Language: English

Topic: Renin-Angiotensin System Studies

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W2462779512