Work

Thiol Redox and pKa Properties of Mycothiol, the Predominant Low‐Molecular‐Weight Thiol Cofactor in the Actinomycetes

Year: 2016

Type: article

Abstract: The thiol pKa and standard redox potential of mycothiol, the major low-molecular-weight thiol cofactor in the actinomycetes, are reported. The measured standard redox potential reveals substantial discrepancies in one or more of the other previously measured intracellular parameters that are relevant to mycothiol redox biochemistry.

Source: ChemBioChem

DOI: 10.1002/cbic.201600228

Authors: Sunil V. Sharma, Koen Van Laer, Joris Messens, Chris J. Hamilton

Institutions: University of East Anglia, Norwich Research Park, Vrije Universiteit Brussel, German Cancer Research Center, VIB-VUB Center for Structural Biology

Language: English

Topic: Redox biology and oxidative stress

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: green

Funders: Leverhulme Trust, Vlaams Instituut voor Biotechnologie, Vlaamse regering

Award: G4406467591