Decrease in circulating myeloid dendritic cell precursors in patients with intracranial large artery atherosclerosis.
Year: 2015
Type: article
Study design: Observational Study
Abstract: Intracranial large artery atherosclerosis (ILAA) is a major cause of ischemic cerebrovascular disease. The aim of this study was to investigate whether the levels of circulating dendritic cell precursors (DCP) could reflect the severity of intracranial large artery atherosclerosis (ILAA). For this purpose, a series of angiography were taken to determine the severity and extent of coronary artery and intracranial large artery stenosis, and flow cytometry were taken to determine the levels of circulating mDC precursors and pDC precursors in patients with severe intracranial large artery atherosclerosis (ILAA) (n = 101) and mild intracranial large artery atherosclerosis (ILAA) (n = 123) according to the angiography. Circulating mDC precursors were lower in patients with severe intracranial large artery atherosclerosis (ILAA) than in mild intracranial large artery atherosclerosis (ILAA) (P < 0.05), but circulating pDC precursors were not significant differences (P > 0.05). According to these data, circulating mDC precursors could predict the severity of ILAA, which also could be able to reflect the severity of ILAA.
Source: PubMed
Authors: Jin-Xia Zhang, Bing-Ling Li, Zhong-Qiu Lin, Ni Zhang, Xiong Peng, Zhi-Hua Gong, Liu-Cheng Long, Xuan Zhou, Ding-Cheng Xiang
Institution: General Hospital of Guangzhou Military Command
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2463202140