Year: 2007
Type: article
Study design: Observational Study
Abstract: Background: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy affecting 5-10% of premenopausal women.50-90% characterized by insulin resistance.Obesity is common among patient with PCOS.Objective: To investigate insulin resistance (IR) and β -cell function (βF) in upper -body obese women with PCOS.Materials and Methods: 51 Iraqi women with PCOS and 25 healthy age-matched controls were recruited in crosssectional study from infertility clinic population.PCOS patients were divided into 2 groups according to waist-tohip ratio (WHR); either > 0.85 (upper body obesity) or ≤ 0.85 (lower body obesity).Fasting insulin, glucose, free testosterone (free T) were measured.Homeostatic model assessment values of IR (HOMA-IR) and percent β-cell function (HOMA -%β cell) were calculated.Statistical analyses used were student-t test, analysis of variance (ANOVA), Pearson Correlation coefficient (r) as appropriate.Results: Patients with PCOS and Controls differed significantly in all parameters studied, except fasting glucose, FSH (p < 0.05).60% of obese PCOS had upper -body obesity were found to be more insulin resistance and have higher β cell function than those with lower -body obesity who in turn were more insulin resistance than control women (p<0.0005 by ANOVA).In PCOS, upper -body obesity were correlated positively and significantly with (HOMA-IR), (HOMA -%β cell) and free T. (r=0.371,p=0.002;r=0.383,p=0.001;r=0.254;p=0.027 respectively).76.5% of patient with PCOS had IR from whom 65% had upper -body obesity.Conclusion: About seventy four of patients with PCOS had insulin resistance.Upper-body obesity aggravates insulin resistance and hyperandrogenism of patients with PCOS and modulates β-cell function Key words: polycystic ovary syndrome, insulin resistance, upper -body obesity.
Author: Ansam A. Al-Bayatti
Language: English
Subfield: Reproductive Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2463222385