Work

Comparison of analytical techniques for the identification of bioactive compounds from natural products

Year: 2016

Type: article

Abstract: Covering: 2000 to 2016Natural product extracts are a rich source of bioactive compounds. As a result, the screening of natural products for the identification of novel biologically active metabolites has been an essential part of several drug discovery programs. It is estimated that more than 70% of all drugs approved from 1981 and 2006, were either derived from or structurally similar to nature based compounds indicating the necessity for the development of a rapid method for the identification of novel compounds from plant extracts. The screening of biological matrices for the identification of novel modulators is nevertheless still challenging. In this review we discuss current techniques in phytochemical analysis and the identification of biologically active components.

Source: Natural Product Reports

DOI: 10.1039/c6np00016a

Authors: Łukasz Cieśla, Ruin Moaddel

Institutions: Medical University of Lublin, National Institutes of Health, National Institute on Aging

Language: English

Topic: Chromatography in Natural Products

Subfield: Analytical Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging

Awards: G7423759087, Immobilized Proteins In Drug Discovery