Work

Depression and Schizophrenia: Cause, Consequence or Trans-diagnostic Issue?

Year: 2016

Type: review

Abstract: The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognizing depression in schizophrenia bring. Taken together we propose that depression is more than comorbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.

Source: Schizophrenia Bulletin

DOI: 10.1093/schbul/sbw097

Authors: Rachel Upthegrove, Steven Marwaha, Max Birchwood

Institutions: Birmingham and Solihull Mental Health NHS Foundation Trust, University of Birmingham, University of Warwick, Coventry and Warwickshire Partnership NHS Trust

Language: English

Topic: Schizophrenia research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Institute for Health and Care Research