Meta-analysis of rare and common exome chip variants identifies S1PR4 and other loci influencing blood cell traits
Year: 2016
Type: review
Study design: Observational Study
Source: Nature Genetics
DOI: 10.1038/ng.3607
Authors: Nathan Pankratz, Ursula M Schick, Yingchang Lu, Erwin P Bottinger, Ruth J F Loos, Alex P Reiner, Yi Zhou, Elliott J Hagedorn, Bella Hu, Vy M Nguyen, Amanda M Rosa Di Sant, Leonard I Zon, Wei Zhou, Tarunveer Singh Ahluwalia, Jette Bork-Jensen, Niels Grarup, Torben Hansen, Oluf Pedersen, Maria Laura Allende, Richard L Proia, Paul L Auer, Jennifer A Brody, James S Floyd, Bruce M Psaty, Ming-Huei Chen, John D Eicher, Andrew D Johnson, Xiaoling Zhang, L Adrienne Cupples, Christopher J O'Donnell, Vinna Clavo, Kristina Hunker, Min-Lee Yang, Santhi K Ganesh, Maarten Leusink, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Ani Manichaikul, Stephen S Rich, Riccardo E Marioni, Ian J Deary, David C Liewald, John M Starr, Mike A Nalls, Raha Pazoki, Frank J A van Rooij, Oscar H Franco, Albert Hofman, Fernando Rivadeneira, Andre G Uitterlinden, Abbas Dehghan, Albert Vernon Smith, Vilmundur Gudnason, Yan Zhang, Jia Jia, Yong Huo, Folkert W Asselbergs, Eric Boerwinkle, Megan L Grove, Ingrid B Borecki, Mary F Feitosa, Judy Wang, Mary Cushman, Paul I W de Bakker, Mattijs E Numans, Liguang Dong, Nora Franceschini, Melissa E Garcia, Tamara B Harris, Lenore J Launer, Rebecca D Jackson, Mika Kähönen, Allan Linneberg, Betina Heinsbæk Thuesen, Yongmei Liu, Olli T Raitakari, Jerome I Rotter, Kent D Taylor, Russell P Tracy, Jiansong Wang, James G Wilson
Institutions: University of Minnesota, Fred Hutch Cancer Center, Icahn School of Medicine at Mount Sinai, University of Washington, Harvard University, University of Michigan, University of Copenhagen, Novo Nordisk Foundation Center for Basic Metabolic Research, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, University of Wisconsin–Milwaukee, Group Health Cooperative, Kaiser Permanente Washington Health Research Institute, Boston University, Framingham Heart Study, National Heart, Lung, and Blood Institute, VA Boston Healthcare System, Michigan Medicine, Utrecht University, Tampere University, Fimlab (Finland), University of Tampere, University of Virginia, The University of Queensland, University of Edinburgh, National Institute on Aging, Erasmus MC, University of Iceland, Icelandic Heart Association, Peking University First Hospital, University Medical Center Utrecht, Netherlands Heart Institute, University College London, Baylor College of Medicine, The University of Texas Health Science Center at Houston, University of Vermont, Peking University Shougang Hospital, Leiden University Medical Center, University of North Carolina at Chapel Hill, The Ohio State University, Tampere University Hospital, Glostrup Hospital, Rigshospitalet, Capital Region of Denmark, Wake Forest University Health Sciences, Wake Forest University, University of Turku, Turku University Hospital, University of California, Los Angeles, The Lundquist Institute, Harbor–UCLA Medical Center, University of Mississippi Medical Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: bronze
Funders: U.S. Department of Health and Human Services, University of Minnesota, Nederlandse Organisatie voor Wetenschappelijk Onderzoek, Lundbeckfonden, National Institutes of Health, Biotechnology and Biological Sciences Research Council, National Institute on Aging, National Heart, Lung, and Blood Institute, National Human Genome Research Institute, National Cancer Institute, National Institute of Diabetes and Digestive and Kidney Diseases, National Center for Research Resources, National Center for Advancing Translational Sciences, NHLBI Division of Intramural Research
Awards: G1028663679, G1052397333, G112182703, G1135917780, G1220223050, G1243299691, MESA, Genetic Determinants of Visceral Adiposity, CORONARY HEART DISEASE AND STROKE, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G1303440240, A CENTER OF MOLECULAR DEVELOPMENTAL HEMATOPOIESIS, G1409423729, G1410181327, DYNAMICS OF HEALTH,AGING, AND BODY COMPOSITION, G1527150935, THE AGES STUDY - THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENUM, CORONARY HEART DISEASE AND STROKE, G1686417863, G1691174148, G173303992, G1941623656, G1947136479, Customized stem cells for clinical application in blood disorders, G2070131968, DYNAMICS OF HEALTH, AGING, AND BODY COMPOSITION, Rare variants and NHLBI traits in deeply phenotyped cohorts, G2194386449, CORONARY HEART DISEASE &STROKE IN PEOPLE AGED 65-84, G2262782284, Genetic Studies of The Impact of Hematologic Traits On Cardiovascular Disease, G2273349799, Genetic Architecture of Adiposity in Multiple Large Cohorts, G232264632, G2391884931, G2412562481, MESA, Clinical and Translational Science Award, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), G250924255, CORONARY HEART DISEASE &STROKE IN THE ELDERLY, G2818629771, MESA, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G3045517347, WGA Study to Identify Genetic Variants Associated with CV Events in CHS, G3114902838, HEALTH ABC--COORDINATING UNIT, Prospective meta-analyses of drug-gene interactions: CHARGE GWAS consortium, G3220743633, UCLA Clinical and Translational Science Institute, G3342643523, G3395363768, G3410686264, G3462919067, G3540328069, G3545534745, G3647016462, G3687594596, MESA, CENTRAL BLOOD ANALYSIS LABORATORY FOR CHS, G399481048, FHS-SCAN Genome Wide Association Scan for Atherosclerosis Pathway Genes, Rare variants and NHLBI traits in deeply phenotyped cohorts, G412187901, DEVELOPMENTAL BIOLOGY OF HUMAN ERYTHROPOIESIS, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), A CENTER OF MOLECULAR HEMATOLOGY, G4512137732, G457330776, G4608159596, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, G5164707915, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G5479317095, G5547620395, G5624510383, G567847597, G5787256936, G581887176, G5909482378, CHARGE consortium: omics discovery for CVD and aging phenotypes, CHS Events Follow-up Study, G6095866717, G619791618, G6226795708, G6359107525, The Framingham Heart Study, MESA, GENOMIC SCAN FOR ATHEROSCLEROSIS PATHWAY GENES IN AFRICAN-AMERICANS FROM FHS-SCAN, G6514094751, G6548750934, CHS-Transition Phase, SNP HEALTH ASSOCIATION RESOURCE (SHARE), G673128162, WHI Sequencing Project (WHISP), G6800011207, G6894932656, A genome-wide association study of non-pathological cognitive ageing, Molecular pathological epidemiology of colorectal cancer, GWAS of Hormone Treatment and CVD and Metabolic Outcomes in the WHI, G7176672723, G7226679574, Embryonic Hematopoiesis, MESA, Exceptional Survival: Trajectories to Functional Aging (CHS All Stars), CHS Events Follow-up Study, Probing The Dark Matter of the Genome in the NHLBI Family Heart Study, G8267674335, A Community Zebrafish Resource for Modeling GWAS Biology, Cancer Prevention Training in Nutrition, Exercise & Genetics, G8536616440, G870807107, Building on GWAS for NHLBI-disease: the CHARGE consortium, Diabetes Research Center (DRC), G945304896
OpenAlex ID: W2463720304