The life cycle of a T cell after vaccination – where does immune ageing strike?
Year: 2016
Type: article
Abstract: Vaccination is the optimal intervention to prevent the increased morbidity and mortality from infection in older individuals and to maintain immune health during ageing. To optimize benefits from vaccination, strategies have to be developed that overcome the defects in an adaptive immune response that occur with immune ageing. Most current approaches are concentrated on activating the innate immune system by adjuvants to improve the induction of a T cell response. This review will focus upon T cell-intrinsic mechanisms that control how a T cell is activated, expands rapidly to differentiate into short-lived effector cells and into memory precursor cells, with short-lived effector T cells then mainly undergoing apoptosis and memory precursor cells surviving as long-lived memory T cells. Insights into each step of this longitudinal course of a T cell response that takes place over a period of several weeks is beginning to allow identifying interventions that can improve this process of T cell memory generation and specifically target defects that occur with ageing.
DOI: 10.1111/cei.12829
Authors: C Kim, F Fang, C M Weyand, J J Goronzy
Language: English
Topic: T-cell and B-cell Immunology
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: green
Awards: CD8 T Cells in Rheumatoid Arthritis, G1556766700, G1588279094, G1809139246, G366100091, Oligoclonal T Cell Expansion and Rheumatoid Arthritis, G6241365711, Interactions Between Inflammation, Oxidant Stress and Cardiovascular Disease, G7126395394, G9000017482, G9000123093, G9000150726, Understanding Influenza and SARS-CoV-2 vaccine responses, in vivo and in vitro, The NOTCH Signaling Pathway in Large Vessel Vasculitis, Vaccine and Infection Induced Immunity in the Young and Aged
OpenAlex ID: W2464215535