Seed and soil: A conceptual framework of metastasis for clinicians.
Year: 2013
Type: article
Abstract: Most mortality from cancer is secondary to metastasis. Metastasis refers both to the process by which tumor cells establish themselves at organs distinct from where they originated and to the life-threatening lesions themselves. Metastases are often resistant to conventional therapies, highlighting a key distinction between these progeny lesions and the primary tumor from which they arose. Here, we summarize recent advances in understanding and targeting primary tumors and the mechanisms and therapeutic challenges of metastasis.
Source: Europe PMC (PubMed Central)
Authors: Farhoud Faraji, Joel C Eissenberg
Institution: Saint Louis University
Language: English
Topic: Cancer Cells and Metastasis
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2465001898