Work

Visible-Light-Mediated Synthesis of Amidyl Radicals: Transition-Metal-Free Hydroamination and N -Arylation Reactions

Year: 2016

Type: article

Abstract: The development of photoredox reactions of aryloxy-amides for the generation of amidyl radicals and their use in hydroamination-cyclization and N-arylation reactions is reported. Owing to the ease of single-electron-transfer reduction of the aryloxy-amides, the organic dye eosin Y was used as the photoredox catalyst, which results in fully transition-metal-free processes. These transformations exhibit a broad scope, are tolerant to several important functionalities, and have been used in the late-stage modification of complex and high-value N-containing molecules.

Source: Journal of the American Chemical Society

DOI: 10.1021/jacs.6b04920

Authors: Jacob Davies, Thomas D. Svejstrup, Daniel Fernandez Reina, Nadeem S. Sheikh, Daniele Leonori

Institutions: University of Manchester, King Faisal University

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500