Work

Serum levels of long pentraxin PTX3 in patients with polymyalgia rheumatica.

Year: 2010

Type: article

Abstract: OBJECTIVES: To evaluate PTX3 feasibility to provide a prognostic tool in PMR clinical practice. METHODS: Circulating PTX3 levels were measured in 93 PMR patients at disease onset and during corticosteroid therapy and in 46 normal controls (NC) by ELISA. RESULTS: No difference in PTX3 concentrations was observed between NC and PMR either at disease onset and during follow-up or between groups of patients defined according to the presence of recurrence/relapse. CONCLUSIONS: PTX3 serum levels do not increase significantly in active PMR. Further studies on patients with giant-cell arteritis could evaluate whether large vessel involvement may be associated to increased PTX3 levels.

Source: PubMed

Authors: L Pulsatelli, G Peri, P Macchioni, L Boiardi, C Salvarani, F Cantini, A Mantovani, R Meliconi

Institutions: Istituto Ortopedico Rizzoli, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Santa Maria Nuova Hospital, Ospedale Misericordia e Dolce, IRCCS Humanitas Research Hospital

Language: English

Topic: Biomarkers in Disease Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2465585670

FWCI: 0.642

Cites: 14

Cited by: 16

Related to: 10