Work

Design and engineering of artificial oxygen-activating metalloenzymes

Year: 2016

Type: review

Abstract: Many efforts are being made in the design and engineering of metalloenzymes with catalytic properties fulfilling the needs of practical applications. Progress in this field has recently been accelerated by advances in computational, molecular and structural biology. This review article focuses on the recent examples of oxygen-activating metalloenzymes, developed through the strategies of de novo design, miniaturization processes and protein redesign. Considerable progress in these diverse design approaches has produced many metal-containing biocatalysts able to adopt the functions of native enzymes or even novel functions beyond those found in Nature.

Source: Chemical Society Reviews

DOI: 10.1039/c5cs00923e

Authors: Flavia Nastri, Marco Chino, Ornella Maglio, Ambika Bhagi-Damodaran, Yi Lu, Angela Lombardi

Institutions: University of Naples Federico II, Institute of Biostructure and Bioimaging, National Research Council, University of Illinois Urbana-Champaign

Language: English

Topic: Metal-Catalyzed Oxygenation Mechanisms

Subfield: Inorganic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Science Foundation, European Cooperation in Science and Technology, National Institute of General Medical Sciences

Awards: Biosynthetic Models of Heteronuclear Metalloenzymes in Multi-electron Processes, G2541019433, Tuning Redox Potentials of Metal Centers in a Single Protein