Work

Evaluation of CEDIA and DRI Drugs of Abuse Immunoassays for Urine Screening on a Thermo Indiko Plus Analyzer

Year: 2016

Type: article

Abstract: BACKGROUND: For analysis of urine samples during abstinence control for driving ability assessment (medical and psychological assessment, MPA), a reliable screening method for ethyl glucuronide and drugs of abuse (cannabinoids, opiates, cocaine, amphetamines, methadone, and benzodiazepines) is needed. METHODS: In this study CEDIA and DRI immunoassays were applied on a Thermo Fisher Scientific Indiko Plus analyzer. Precision and accuracy as well as sensitivity and specificity at the required cut-offs for the MPA were evaluated. RESULTS: The specificity was satisfactory and ranged from 91% for methamphetamine to 100% for opiates, cocaine metabolite, amphetamine, EDDP, and benzodiazepines. Moreover, sensitivity was 100% for all assays except for cannabinoids (91%). CONCLUSION: The presented method can therefore be recommended for abstinence control.

Source: Journal of Clinical Laboratory Analysis

DOI: 10.1002/jcla.22021

Authors: Katharina M. Köhler, Raija Hammer, Kathrin Riedy, Volker Auwärter, Merja A. Neukamm

Institutions: University of Freiburg, University Medical Center Freiburg

Language: English

Topic: Forensic Toxicology and Drug Analysis

Subfield: Toxicology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Corporación Ecuatoriana para el Desarrollo de la Investigación y la Academia, Albert-Ludwigs-Universität Freiburg