P3‐093: Plasma metabolomic markers associated with cognitive performance and resting state cerebral blood flow during aging: The baltimore longitudinal study of aging
Year: 2015
Type: article
Abstract: We recently showed that plasma concentrations of the phosphatidylcholines [PC16:0/20:5; PC16:0/22:6; PC18:0/22:6] are reduced in Alzheimer's disease relative to healthy controls. We aimed to extend these findings by testing associations between plasma concentrations of these PCs with cognition and resting state cerebral blood flow (rCBF) in non-demented individuals. Plasma PC concentrations [PC16:0/20:5; PC16:0/22:6; PC18:0/22:6], cognition [California Verbal Learning Test (CVLT), Trails A&B, and the Mini-Mental State Examination (MMSE)], and rCBF (measured by O-Water Positron Emission Tomography) were measured in participants within the Baltimore Longitudinal Study of Aging Neuroimaging Substudy (BLSA-NI), who were non-demented at baseline (mean follow-up=7.8yrs, Baseline n=110, age=49-89yrs; Visit 2 n=107, age=52-92yrs; Visit 3 n=77, age=56-94). Associations of plasma PC concentrations with cognition were examined using mixed-effects linear regression. Associations between plasma PC concentrations and rCBF were analyzed voxel-wise using Statistical Parametric Mapping (SPM5). Lower baseline plasma PC concentrations were associated with lower baseline memory performance. Lower baseline plasma PC concentrations were also associated with reduced baseline rCBF within several brain regions including the right superior temporal gyrus, bilateral middle temporal and parahippocampal gyri, right insula, bilateral inferior frontal gyri, right medial frontal gyrus, left gyrus rectus, left precentral and fusiform gyri. We did not find strong associations between plasma PC concentrations and longitudinal changes in cognitive performance. Lower plasma concentrations of the candidate AD biomarkers, PC16:0/20:5, PC16:0/22:6 and PC18:0/22:6 are associated with poorer memory performance and reduced cerebral blood flow within brain regions including those related to memory performance in non-demented older individuals. Dysregulation of peripheral PC metabolism appears to be associated with widespread reduction in brain function and may be a common feature of both AD and age-associated cognitive impairment.
Source: Alzheimer s & Dementia
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2466196641