Role of glycogen content on glucose uptake and glycogen synthase in skeletal muscles: The effect of contraction and insulin
Year: 2010
Type: dissertation
Abstract: The present thesis is based on 4 papers which have investigated contraction- and\ninsulin-mediated regulations of glucose uptake and GS activation in skeletal muscles\nwith different glycogen contents. The level of glycogen content in skeletal muscle has\na strong effect on the regulation of glucose metabolism. In the present thesis, we have\nshown that low glycogen content strongly increased glucose uptake in epitrochlearis\nmuscle either under insulin and contraction stimulation alone or in combination.\nGLUT4 content was increased in epitrochlearis muscle with low glycogen content\nwhich can contribute the increased glucose uptake. Although insulin-stimulated PKB\nphosphorylation and contraction-stimulated AMPK activation were highest in muscle\nwith low glycogen content, AS160/TBC1D1 phosphorylation was not elevated\ncorrespondingly, suggesting that these key signalling molecules do not determine the\nrate of glucose uptake. Furthermore, low glycogen content prevents the additivity of\nglucose uptake when insulin and contraction were combined.
Source: BIBSYS Brage (BIBSYS (Norway))
Author: Yu‐Chiang Lai
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
Funder: Novo Nordisk
OpenAlex ID: W2466753839