Work

Azaindole synthesis through dual activation catalysis with N-heterocyclic carbenes

Year: 2016

Type: article

Abstract: A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.

Source: Chemical Communications

DOI: 10.1039/c6cc04735a

Authors: Hayden A. Sharma, M. Todd Hovey, Karl A. Scheidt

Institutions: Northwestern University, Chemistry of Life Processes Institute

Language: English

Topic: N-Heterocyclic Carbenes in Organic and Inorganic Chemistry

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funders: National Institutes of Health, National Institute of General Medical Sciences

Awards: G682315649, G9000089925