Hippocampal transcriptome-guided genetic analysis of correlated episodic memory phenotypes in Alzheimer's disease
Year: 2015
Type: article
Study design: Observational Study
Abstract: As the most common type of dementia, Alzheimer's disease (AD) is a neurodegenerative disorder initially manifested by impaired memory performances. While the diagnosis information indicates a dichotomous status of a patient, memory scores have the potential to capture the continuous nature of the disease progression and may provide more insights into the underlying mechanism. In this work, we performed a targeted genetic study of memory scores on an AD cohort to identify the associations between a set of genes highly expressed in the hippocampal region and seven cognitive scores related to episodic memory. Both main effects and interaction effects of the targeted genetic markers on these correlated memory scores were examined. In addition to well-known AD genetic markers APOE and TOMM40, our analysis identified a new risk gene NAV2 through the gene-level main effect analysis. NAV2 was found to be significantly and consistently associated with all seven episodic memory scores. Genetic interaction analysis also yielded a few promising hits warranting further investigation, especially for the RAVLT list B Score.
Source: Frontiers in Genetics
Language: English
Subfield: Psychiatry and Mental health
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $1,042
Funders: National Science Foundation, U.S. Department of Defense, Foundation for the National Institutes of Health, Alzheimer's Association, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, Biogen, University of Southern California, F. Hoffmann-La Roche, Medpace, Meso Scale Diagnostics, Synarc, Alzheimer's Disease Neuroimaging Initiative, BioClinica, Novartis Pharmaceuticals Corporation, Dartmouth College, Eisai, Servier, IXICO, National Institutes of Health, Genentech, University of California, San Diego, Canadian Institutes of Health Research, National Institute on Aging, National Institute of Biomedical Imaging and Bioengineering, U.S. National Library of Medicine, National Center for Advancing Translational Sciences
Awards: G1012222616, G104586243, G1308337445, Indiana Alzheimer Disease Center, Bioinformatics Strategies for Multidimensional Brain Imaging Genetics, G1554142629, G1593117279, G1650819308, G1654311910, G1823308732, III: Small: Collaborative Research: A Large-Scale Data Mining Framework for Genome-Wide Mapping of Multi-Modal Phenotypic Biomarkers and Outcome Prediction, Alzheimer's Disease Neuroimaging Initiative, G2022000225, G2100670906, G2105457377, G2189010064, G2340207221, G2409989180, G2423387114, G2522063444, Indiana Clinical and Translational Sciences Institute, G2822121521, G2835601961, G29951154, G3130427885, G3131374986, G3146424788, G3216574877, G3553156159, G3582805754, Integration of Bio-, Medical, and Imaging Informatics for Complex Diseases, G3705772492, G3710456697, G3752451908, G3779651404, G3870774570, G3908963977, G3966393351, Integration of Bio-, Medical, and Imaging Informatics for Complex Diseases, G4071507417, G4119534169, G43180419, G4401988282, G4475667458, G4501223628, THE NCAA-DOD GRAND ALLIANCE: CONCUSSION ASSESSMENT, RESEARCH, AND EDUCATION (CARE) CONSORTIUM, G4800177743, G4860885537, Machine Learning Prediction of Cancer Susceptibility, G5207404921, G5209990037, G528601746, G5324093878, G5365730499, EFFECTS OF TRAUMATIC BRAIN INJURY (TBI) AND POST TRAUMATIC STRESS DISORDER (PTSD) ON ALZHEIMER'S DISEASE (AD) IN VETERANS USING IMAGING AND BIOMARKERS IN THE AD NEUROIMAGING INITIATIVE (ADNI)", G5389965057, Bioinformatics Strategies for Genome Wide Association Studies, G5520316217, G5654639750, G5740349702, G5850682332, G613619302, G6173816828, G6210868510, G6371410416, G6412110892, G6447063303, G6719828067, G6792506723, G6798853303, G6899163935, G6948409098, G7268282379, G7298697282, G7414321945, Memory Circuitry in MCI and Early Alzheimerâs Disease Prodrome: Molecular Drivers, G764699806, Amyloid Imaging, VMCI, and Analysis for ADNI, G7799614282, G781725486, G8107776361, G8228018387, G8281378126, G8301434335, G839208290, G8636843673, G8852128998, G8895907669, G8897063270, G8957659042, G9000039018, G9000074849, G9000122335, G920654007
OpenAlex ID: W1481651785