Work

An overall and dose-response meta-analysis for thyrotropin and thyroid cancer risk by histological type

Year: 2016

Type: article

Study designs: Systematic Review, Meta-Analysis

Abstract: // Na Hu 1, 2, * , Zhan-Ming Li 3, * , Jin-Feng Liu 1, 2 , Zhen-Zhen Zhang 1, 2 , Li-Shun Wang 1 1 Institute of Biomedical Sciences, Minhang Hospital, Fudan University, Shanghai, P.R. China 2 School of Public Health Taishan Medical University, Shandong, P.R. China 3 Ruijin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, P.R. China * These authors contributed equally to this work Correspondence to: Li-Shun Wang, email: [email protected] Keywords: thyroid cancer, serum thyrotropin, meta-analysis, differentiated thyroid carcinoma, papillary thyroid carcinoma Received: December 16, 2015 Accepted: June 12, 2016 Published: June 24, 2016 ABSTRACT Thyrotropin (TSH) is thought as a risk factor for thyroid cancer. However, the effect of serum TSH might depend on histological types of thyroid cancer. We searched for related studies including serum TSH as an exposure and thyroid cancer as a result in PUBMED, EMBASE and Chinese National Knowledge Infrastructure up to April 21, 2016. This meta-analysis included 22 articles with 53,538 participants. When comparing all histological thyroid cancer, the pooled odds ratios of thyroid cancer in patients with nodules was found to increase significantly with higher serum TSH concentrations for differentiated thyroid carcinoma (1.88 vs .1.48, P = 0.0000) and papillary thyroid carcinoma (2.08 vs. 1.48, P = 0.0006). Each 1 mU/L increase of serum TSH was associated with 14% greater risk of thyroid cancer for all histological thyroid cancer, 16% for differentiated thyroid carcinoma and 22% for papillary thyroid carcinoma. In addition, high serum TSH was associated with a reduced risk for follicular thyroid carcinoma (OR = 0.73, 95% CI: 0.52, 1.02). This meta-analysis suggested high serum TSH concentration is risky for papillary thyroid carcinoma but not for follicular thyroid carcinoma.

Source: Oncotarget

DOI: 10.18632/oncotarget.10282

Authors: Na Hu, Zhan-Ming Li, Jin-Feng Liu, Zhen-Zhen Zhang, Li-Shun Wang

Institutions: Fudan University, Taishan Medical University, Shanghai Jiao Tong University, Ruijin Hospital

Language: English

Topic: Thyroid Cancer Diagnosis and Treatment

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: National Natural Science Foundation of China