Work

Synthesis of a Small Library of Imidazolidin-2-ones using Gold Catalysis on Solid Phase

Year: 2016

Type: article

Abstract: An efficient and high-yielding solid phase synthesis of a small library of imidazolidin-2-ones and imidazol-2-ones was carried out employing a high chemo- and regioselective gold-catalyzed cycloisomerization as a key step. Polymer-supported amino acids derivatized with several alkyne functionalities combined with tosyl- and phenylureas have been subjected to gold-catalysis exhibiting exclusively C-N bond formation. The present work proves the potential of solid phase synthesis and homogeneous gold catalysis as an efficient and powerful synthetic tool for the generation of drug-like heterocycles.

Source: ACS Combinatorial Science

DOI: 10.1021/acscombsci.6b00062

Authors: Agustina La-Venia, Noelia S. Medran, Viktor Krchňák, Sebastián A. Testero

Institutions: Consejo Nacional de Investigaciones Científicas y Técnicas, National University of Rosario, Institute of Molecular and Translational Medicine, Palacký University Olomouc, University of Notre Dame

Language: English

Topic: Catalytic Alkyne Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green