The Acetazolamide Challenge: Imaging Techniques Designed to Evaluate Cerebral Blood Flow Reserve
Year: 1989
Type: article
Abstract: Cerebral blood flow was analyzed by the stable xenon (Xe)/CT scanning technique in 29 patients with significant vascular lesions before and after administration of an acetazolamide (Diamox) vasodilatory challenge. Three response types were identified: I, normal flow before Diamox with flow augmentation after Diamox; II, low flow before Diamox with flow augmentation after Diamox; and III, low or normal flow before Diamox with no augmentation or decreased flow after Diamox. Twenty-four percent of the patients studied qualified for category III. We believe that patients in this category represent a group of individuals without blood flow reserve whose clinical management should include careful consideration of their hemodynamic status. The Xe/CT scanning technique with the addition of Diamox flow challenge is a clinically accessible and effective method for assessing cerebral blood flow and blood flow reserve.
Source: PubMed Central
Authors: Jeffrey M. Rogg, Michael J. Rutigliano, Howard Yonas, David W. Johnson, Susan Pentheny, Richard E. Latchaw
Institutions: Brown University, Rhode Island Hospital, University of Pittsburgh
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2469853442