Detectable Tenofovir Levels in Breast-Feeding Infants of Mothers Exposed to Topical Tenofovir
Year: 2016
Type: article
Study design: Clinical Trial
Abstract: Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity (milk), adverse events (AEs), and adherence were measured for 17 HIV-1-seronegative breast-feeding mother-infant pairs. Tenofovir use was well-tolerated and detected at low levels in maternal serum, milk, and infant serum but demonstrated no anti-HIV activity in milk.
DOI: 10.1128/aac.00645-16
Institutions: Johns Hopkins University, RTI International, University of Alabama at Birmingham, University of Pittsburgh, Fred Hutch Cancer Center, National Institutes of Health, National Institute of Allergy and Infectious Diseases, Family Health International 360, Eastern Virginia Medical School, Contraception Research and Development, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Language: English
Subfield: Infectious Diseases
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2469869164