Work

Studies of Human Papovavirus Tumor Antigen in Experimental and Human Cerebral Neoplasms

Year: 1976

Type: article

Abstract: Three types of papovaviruses (JC, BK, and SV40) have been isolated from man. All three are oncogenic in hamsters, cause frequent infection of man, and share a common T antigen. Augmentation of the expression of T antigen by in vitro cultivation of SV40-induced tumors of hamsters suggested that growing human brain tumors in vitro might provide an effective screening technique for the SV40 virus. In a series of human brain tumors examined in cryostat sections and in tissue culture, T antigen could not be demonstrated, suggesting that by this immunofluorescent technique SV40 was not implicated in the etiology of these tumors.

Source: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

DOI: 10.1017/s0317167100025853

Authors: L.E. Becker, O. Narayan, R.T. Johnson

Institutions: Johns Hopkins University, University of Toronto, Johns Hopkins Medicine

Language: English

Topic: Polyomavirus and related diseases

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W2470647353