The default mode network and salience network in schizophrenia : DMN functional dysconnectivity
Year: 2013
Type: dissertation
Study design: Observational Study
Abstract: The default mode network (DMN) is a network in the brain associated with activity during the so-called resting state, also called a “task negative” network. This network has been shown to decrease in activity when engaged in a task (i.e. cognitive task), and increases when at rest. Recent studies have found that the DMN in patients with schizophrenia have shown tendency for a failure of deactivation of the DMN when engaging in various tasks in the scanner. We wanted to explore if the DMN in fact has a tendency for failure of deactivation. In addition to this, we wanted to investigate whether the salience network (SN) has a role in regulating the “switching” between the DMN and task positive networks. Here, data from n= 129 controls and n= 89 patients with DSM- IV schizophrenia which had undergone a working memory paradigm, were analysed with independent component analysis and dual regression approach. \nWe compared the two wm conditions in all three components across groups, followed by comparing components between the HC and SZ groups. We found no significant group differences in the wm conditions when comparing components across groups. However, an interesting pattern of correlation was found within groups between the ADMN and PDMN. We could not confirm a SN contribution to DMN dysfunction, but our findings did not dismiss this possibility.
Author: Sverre Andreas Sydnes Gustavsen
Language: English
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W2470933175