Recapitulating Amyloid ß and Tau Pathology in Human Neural Cell Culture Models—Clinical Implications
Year: 2015
Type: article
Abstract: The "amyloid β hypothesis" of Alzheimer's disease (AD) has been the reigning hypothesis explaining pathogenic mechanisms of AD over the last two decades. However, this hypothesis has not been fully validated in animal models, and several major unresolved issues remain. We recently developed a human neural cell culture model of AD based on a three-dimensional (3D) cell culture system. This unique, cellular model recapitulates key events of the AD pathogenic cascade, including β-amyloid plaques and neurofibrillary tangles. Our 3D human neural cell culture model system provides a premise for a new generation of cellular AD models that can serve as a novel platform for studying pathogenic mechanisms and for high-throughput drug screening in a human brain-like environment.
Source: touchREVIEWS in Neurology
Authors: Se Hoon Choi, Young Hye Kim, Carla D’Avanzo, Jenna Aronson, Rudolph E Tanzi, Doo Yeon Kim, Postdoc Associate, Professor
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
Awards: Presenilin Biology and the Mechanisms of Alzheimer's Disease, Altered sodium channel metabolism in Alzheimer's disease, Identification and Characterization of Novel AD Genes, A novel human 3D neural cell culture system for the characterization of AD genes, Alzheimer's BACE1 inhibition regulates neuronal contactin function, G8925355129
OpenAlex ID: W2471021244