Year: 2016
Type: article
Abstract: The objective of the study was to discuss the construction methods, characterization and biocompatibility of silk fibroin-gelatin (SF-G) three-dimensional scaffolds which meet the requirements of bone tissue engineering scaffolds. Silk fibroin (SF) and gelatin (G) were lyophilized at different temperature such as -20 °C, -40 °C, -60 °C, -80 °C then to make the composite scaffold materials crosslinked by genipin and methanol. Then to make composite materials, in order to find out the different temperature and crosslinking agent of SF and G, the following indexes including pore size, porosity, the water absorption and determination of mechanical properties were determined. The most appropriate condition of making SF-G scaffolds was pre-freezing temperature is -40 °C and cross-linked by genipin, which could meet the physicochemical requirements of bone tissue engineering.
Source: Journal of Hard Tissue Biology
DOI: 10.2485/jhtb.25.269
Authors: Yang Du, Xiu-qiu Gao, Zhi-ying Wang, Ding Jin, Shuang Tong, Xu-kai Wang
Institutions: China Medical University, China Medical University
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W2471207023