International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents
Year: 2016
Type: article
Study design: Observational Study
Abstract: BACKGROUND: Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence. METHODS AND RESULTS: Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years). Two novel loci were identified as having genome-wide associations with systolic BP across specific age epochs: rs1563894 (ITGA11, located in active H3K27Ac mark and transcription factor chromatin immunoprecipitation and 5'-C-phosphate-G-3' methylation site) during prepuberty (P=2.86×10(-8)) and rs872256 during puberty (P=8.67×10(-9)). Several single-nucleotide polymorphism clusters were also associated with childhood BP at P<5×10(-3). Using a P value threshold of <5×10(-3), we found some overlap in variants across the different age epochs within our study and between several single-nucleotide polymorphisms in any of the 3 epochs and adult BP-related single-nucleotide polymorphisms. CONCLUSIONS: Our results suggest that genetic determinants of BP act from childhood, develop over the lifecourse, and show some evidence of age-specific effects.
Authors: Priyakumari Ganesh Parmar, H. Rob Taal, Nicholas J. Timpson, Elisabeth Thiering, Terho Lehtimäki, Marcella Marinelli, Penelope A. Lind, Laura D. Howe, Germaine Verwoert, Ville Aalto, Andre G. Uitterlinden, Laurent Briollais, Dave M. Evans, Margie J. Wright, John P. Newnham, John B. Whitfield, Leo-Pekka Lyytikäinen, Fernando Rivadeneira, Dorrett I. Boomsma, Jorma Viikari, Matthew W. Gillman, Beate St Pourcain, Jouke-Jan Hottenga, Grant W. Montgomery, Albert Hofman, Mika Kähönen, Nicholas G. Martin, Martin D. Tobin, Ollie Raitakari, Jesus Vioque, Vincent W.V. Jaddoe, Marjo-Riita Jarvelin, Lawrence J. Beilin, Joachim Heinrich, Cornelia M. van Duijn, Craig E. Pennell, Debbie A. Lawlor, Lyle J. Palmer
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: diamond
Funders: Wellcome Trust, Medical Research Council
Awards: The Avon Longitudinal Study for Parents and Children: An international resource for population genomic and lifecourse epidemiology. Core programme support 2014-2019., What lies behind the causal impact of body mass index (BMI) level and change on human health? Added value from complementary study design and deep metabolomic phenotyping., The Avon Longitudinal Study of Parents and Children: An international resource for population genomics and lifecourse epidemiology. Core Programme Support 2011-2013., G5470336846
OpenAlex ID: W2471488369