The Use of Forelimb Asymmetry Functional Tests to Determine Motor Recovery With Various Drug Treatments Following Endothelin-Induced Stroke
Year: 2012
Type: article
Abstract: Our laboratory has found increased functional recovery post-stroke with Long Evans rats that received a combination of fluoxetine, simvastatin, and vitamin C. The objectives of this study were to test that treatment and other drug combinations on Sprague Dawley rats, to determine whether Forelimb Asymmetry is a reliable behavioral measure for stroke studies, and to determine the most optimal surgical procedure on Sprague Dawley rats. There were more significant increases in functional recovery observed on the Forelimb Asymmetry than on Montoya Staircase behavioral tests, but there were no significant differences between treatment groups and control. The largest number of rats that had at least a 20% deficit was in the group that underwent stroke induction through injecting 1.5ul endothelin into the strereotactic sites AP (0), ML (-2.5), DV (2.0) and AP (1.5), ML (-2.5), DV (2.0) from bregma, which should be utilized in future stroke studies with Sprague Dawley rats.
Author: Kelly Leach
Institution: Wright State University
Language: English
Subfield: Rehabilitation
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W2471509761