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Insulin in the nervous system and the mind: Functions in metabolism, memory, and mood

Year: 2016
Type: review
Abstract: BACKGROUND: Insulin, a pleotrophic hormone, has diverse effects in the body. Recent work has highlighted the important role of insulin's action in the nervous system on glucose and energy homeostasis, memory, and mood. SCOPE OF REVIEW: Here we review experimental and clinical work that has broadened the understanding of insulin's diverse functions in the central and peripheral nervous systems, including glucose and body weight homeostasis, memory and mood, with particular emphasis on intranasal insulin. MAJOR CONCLUSIONS: Implications for the treatment of obesity, type 2 diabetes, dementia, and mood disorders are discussed in the context of brain insulin action. Intranasal insulin may have potential in the treatment of central nervous system-related metabolic disorders.
DOI: 10.1016/j.molmet.2016.06.011
Institutions: Beth Israel Deaconess Medical Center, Harvard University, The Catholic University of Korea Seoul St. Mary's Hospital, Catholic University of Korea, East Carolina University, Gachon University Gil Medical Center
Language: English
Open Access status: gold
Estimated APC paid: $4,270
OpenAlex ID: W2471590266
FWCI: 1.92
Cites: 148
Cited by: 182
Related to: 10